ChloroquineV1, Main, Exploration, bibRecord, 001370

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

Identifieur interne : 001370 ( Main/Exploration ); précédent : 001369; suivant : 001371

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

Auteurs : Chunchun Meng [République populaire de Chine] ; Zhizhi Zhou [République populaire de Chine] ; Ke Jiang [République populaire de Chine] ; Shengqing Yu [République populaire de Chine] ; Lijun Jia [République populaire de Chine] ; Yantao Wu [République populaire de Chine] ; Yanqing Liu [République populaire de Chine] ; Songshu Meng [République populaire de Chine] ; Chan Ding [République populaire de Chine]

Source :

Archives of Virology [ 0304-8608 ] ; 2012-06-01.

RBID : ISTEX:1A493F302411893F95B8D8D71482CD0102E4B57B

Abstract

Abstract: Newcastle disease virus (NDV) can replicate in tumor cells and induce apoptosis in late stages of infection. However, the interaction between NDV and cells in early stages of infection is not well understood. Here, we report that, shortly after infection, NDV triggers the formation of autophagosomes in U251 glioma cells, as demonstrated by an increased number of double-membrane vesicles, GFP-microtubule-associated protein 1 light chain 3 (GFP-LC3) a dot formations, and elevated production of LC3II. Moreover, modulation of NDV-induced autophagy by rapamycin, chloroquine or small interfering RNAs targeting the genes critical for autophagosome formation (Atg5 and Beclin-1) affects virus production, indicating that autophagy may be utilized by NDV to facilitate its own production. Furthermore, the class III phosphatidylinositol 3-kinase (PI3K)/Beclin-1 pathway plays a role in NDV-induced autophagy and virus production. Collectively, our data provide a unique example of a paramyxovirus that uses autophagy to enhance its production.

Url:

https://api.istex.fr/ark:/67375/VQC-RKHHJRB0-Q/fulltext.pdf

DOI: 10.1007/s00705-012-1270-6

Affiliations:

République populaire de Chine

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Newcastle disease virus (NDV) can replicate in tumor cells and induce apoptosis in late stages of infection. However, the interaction between NDV and cells in early stages of infection is not well understood. Here, we report that, shortly after infection, NDV triggers the formation of autophagosomes in U251 glioma cells, as demonstrated by an increased number of double-membrane vesicles, GFP-microtubule-associated protein 1 light chain 3 (GFP-LC3) a dot formations, and elevated production of LC3II. Moreover, modulation of NDV-induced autophagy by rapamycin, chloroquine or small interfering RNAs targeting the genes critical for autophagosome formation (Atg5 and Beclin-1) affects virus production, indicating that autophagy may be utilized by NDV to facilitate its own production. Furthermore, the class III phosphatidylinositol 3-kinase (PI3K)/Beclin-1 pathway plays a role in NDV-induced autophagy and virus production. Collectively, our data provide a unique example of a paramyxovirus that uses autophagy to enhance its production.</div>
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Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri